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- Title
Prédiction de la résistance à la chimiothérapie des tumeurs trophoblastiques gestationnelles (TTG) de bas risque par l'analyse de la cinétique des hCG.
- Authors
You, B.; Colomban, O.; Wilbaux, M.; Hénin, E.; Tod, M.; Freyer, G.; Hajri, T.; Massardier, J.; Golfier, F.
- Abstract
Early determination of the resistance risk to firstline chemotherapy in patients with low-risk gestational trophoblastic disease would be helpful. The strategies based on one hCG time point measured during the 1st or the 7th week of treatment are not reproducible enough. Model-based approaches that enable calculation of the mathematical equations of hCG individual kinetics are promising. The reproducibility of the early predictive value of modelled kinetic parameters was shown in three large international studies. It should be possible to define for any patient her risk of resistance by integrating the hCG values measured during the first 50 treatment days in a program. An international validation of this concept is planned.
- Publication
Oncologie (Tech Science Press), 2014, Vol 16, Issue 6, p300
- ISSN
1292-3818
- Publication type
Article
- DOI
10.1007/s10269-014-2408-9