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- Title
Whole‐exome sequencing and hyperemesis gravidarum: Is there a role of hCG?
- Authors
Deruelle, Philippe; Tranchant, Audrey
- Abstract
Their data exclude a direct causal role of hCG but cannot rule out that hCG may alter the GDF15/GFRAL/RET pathway and contribute to the symptoms. We thank Fejzo et al. for their paper 'Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum,'[1] which demonstrates that a genetic predisposition of GDF15/GFRAL/RET signalling is involved in Hyperemesis Gravidarum (HG), confirming their previous study.[2] They also added that, as no other exome-wide significant or causal variants in >=10 cases were identified, their study does not support the two predominant historical theories that HG has a psychological origin or is caused by the pregnancy hormone human chorionic gonadotropin (hCG). The functioning of the GDF15/GFRAL/RET pathway is imperfectly understood.[6] Little is known about whether hCG may influence or be influenced by the GDF15/GFRAL/RET pathway.
- Subjects
MORNING sickness; CHORIONIC gonadotropins
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2023, Vol 130, Issue 7, p842
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/1471-0528.17379