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- Title
Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis.
- Authors
Naruo Tokuyasu; Kohei Shomori; Kuniki Amano; Soichiro Honjo; Teruhisa Sakamoto; Joji Watanabe; Masataka Amisaki; Masaki Morimoto; Ei Uchinaka; Takuki Yagyu; Hiroaki Saito; Hisao Ito; Yoshiyuki Fujiwara
- Abstract
Background Indirubin, a constituent of the Chinese herbal medicine "Qing-Dai," has anti-cancer and anti-inflammatory activities. We aimed to evaluate the efficacy of indirubin for ameliorating colonic inflammation in a mouse model of inflammatory bowel disease. Methods Mice with dextran sulfate sodium (DSS)- induced acute and chronic colitis were treated with indirubin in their diet. Clinical and histologic changes were evaluated. In addition, colon levels of interleukin-6, a critical pro-inflammatory mediator, was detected by enzyme-linked immunosorbent assay. Results In the model of acute colitis, indirubin treatment improved the loss of body weight. Histology of colonic tissue revealed that indirubin treatment improved the histology grading of colitis (P = 0.02), the extent of submucosal fibrosis (P = 0.018), the number of mucosal toluidine blue-positive cells (P = 0.004) and colon length (P = 0.01). In the model of chronic colitis, indirubin treatment had no significant effect on pathologic findings except for colon length (P = 0.003). However, indirubin administration significantly reduced colon levels of interleukin-6 in the chronic-colitis model (P = 0.001). Conclusion Our study clearly showed that oral intake of indirubin can improve murine DSS-induced colitis (which mimics human inflammatory bowel disease).
- Subjects
INDIRUBIN; HERBAL medicine; INFLAMMATORY bowel diseases; ENZYME-linked immunosorbent assay; FIBROSIS
- Publication
Yonago Acta Medica, 2018, Vol 61, Issue 2, p128
- ISSN
0513-5710
- Publication type
Article
- DOI
10.33160/yam.2018.06.005