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- Title
富 精 氨 酸 小 肽 对 肉 鸡 肝 脏 功 能 的 保 护 作 用.
- Authors
战晓燕; 滑志民; 陈菊红; 刘志国
- Abstract
In order to investigate the protective effects of arginine-rich small peptide (ARSP) on liver functions of broilers, a total of 120 one-day-old broilers were randomly divided into 4 groups (3 repli‐ cates per group) according to a 2×2 factorial arrangement. Broilers were fed a basal diet with or without supplementation of 0.5% arginine-riching small pepide (ARSP), and were intraperitoneally injected with 1 mg/kg BW lipopolysaccharide (LPS) or the same amount of saline during 27-31 days of age. Serum and liver samples were collected following 3 h and 12 h of injection. The results showed that LPS injection significantly increased the activities of aspartate aminotransferase (AST) together with alanine amino‐ transferase (ALT) or alkaline phosphatase (ALP) in serum (P<0.05). At 3 h after injection, ARSP treat‐ ment significantly reduced serum ALP activity (P<0.05) and tended to reduce serum AST activity (P= 0.063). LPS injection significantly increased the contents of various interleukins (suchas IL-1β, IL-6 and IL-8) and TNF-α, as well as increased the mRNA expression of various interleukins (suchas IL1β, IL-6 and IL-8) and inflammatory signal molecules (such as TLR2, TLR4 and NF-κB p65) in the liver (P<0.05). However, ARSP treatment significantly alleviate the changes of the above indexes caused by LPS (P<0.05). The above results suggested that supplemental 0.5% ARSP could attenuate LPS-induced hepatic inflammatory damage of broilers by inhibiting TLR2/NF-κB and/or TLR4/NF-κB pathway.
- Publication
Feed Industry, 2023, Vol 44, Issue 24, p49
- ISSN
1001-991X
- Publication type
Article
- DOI
10.13302/j.cnki.fi.2023.24.008