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- Title
Association Between Variation in Red Cell Size and Multiple Aging-Related Outcomes.
- Authors
Kim, Kyoung Min; Lui, Li-Yung; Browner, Warren S; Cauley, Jane A; Ensrud, Kristine E; Kado, Deborah M; Orwoll, Eric S; Schousboe, John T; Cummings, Steven R; Osteoporotic Fractures in Men (MrOS) Study Research Group
- Abstract
<bold>Background: </bold>We tested whether greater variation in red blood cell size, measured by red cell distribution width (RDW), may predict aging-related degenerative conditions and therefore, serve as a marker of biological aging.<bold>Methods: </bold>Three thousand six hundred and thirty-five community-dwelling older men were enrolled in the prospective Osteoporotic Fractures in Men Study. RDW was categorized into 4 groups (≤13.0%, 13.1%-14.0%, 14.1%-15.0%, and ≥15.1%). Functional limitations, frailty, strength, physical performance, and cognitive function were measured at baseline and 7.4 years later. Falls were recorded in the year after baseline; hospitalizations were obtained for 2 years after baseline. Mortality was assessed during a mean of 8.3 years of follow-up.<bold>Results: </bold>Participants with greater variability in red cell size were weaker, walked more slowly, and had a worse cognitive function. They were more likely to have functional limitations (35.2% in the highest RDW category vs 16.0% in the lowest, p < .001) and frailty (30.3% vs 11.3%, p < .001). Those with greater variability in red cell size were more likely to develop new functional limitations and to become frail. The risk of having 2 or more falls was also greater (highest 19.2% vs lowest 10.3%, p < .001). The risk of hospitalization was higher in those with the highest variability (odds ratio [95% confidence interval], 1.8 [1.3-2.5]) compared with the lowest. Variability in red cell size was related to total and cause-specific mortality.<bold>Conclusion: </bold>Greater variability in red cell size is associated with diverse aging-related outcomes, suggesting that it may have potential value as a marker for biological aging.
- Subjects
CELL size; ERYTHROCYTES; BLOOD cell count; COGNITIVE ability; BONE fractures
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2021, Vol 76, Issue 7, p1288
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glaa217