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- Title
Tumour suppressors: Mob-handed?
- Authors
Cunliffe, Lesley
- Abstract
The article focuses on the Mob tumor suppressor superfamily which has more than 130 members. Researchers have identified the mob as tumor suppressor (MATS) gene in fruitflies as a spontaneous lethal mutation that increased cell proliferation and caused tumour development in many organs. The MATS-mutant flies have high levels of key cell-cycle regulators such as cyclins, and show impaired cellular differentiation. Genetic-mapping experiments in the fruitfly identified MATS as the CG13852 gene, an assignment that was confirmed using CG13852 cDNA to rescue the MATS mutants.
- Subjects
TUMOR suppressor genes; FRUIT flies; GENETIC mutation; CELL proliferation; TUMOR growth; CYCLINS
- Publication
Nature Reviews Cancer, 2005, Vol 5, Issue 5, p334
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc1617