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- Title
Regional and mucosal memory T cells.
- Authors
Sheridan, Brian S; Lefrançois, Leo
- Abstract
After infection, most antigen-specific memory T cells reside in nonlymphoid tissues. Tissue-specific programming during priming leads to directed migration of T cells to the appropriate tissue, which promotes the development of tissue-resident memory in organs such as intestinal mucosa and skin. Mechanisms that regulate the retention of tissue-resident memory T cells include transforming growth factor-? (TGF-?)-mediated induction of the E-cadherin receptor CD103 and downregulation of the chemokine receptor CCR7. These pathways enhance protection in internal organs, such as the nervous system, and in the barrier tissues-the mucosa and skin. Memory T cells that reside at these surfaces provide a first line of defense against subsequent infection, and defining the factors that regulate their development is critical to understanding organ-based immunity.
- Subjects
T cells; MUCOUS membranes; ANTIGENS; NONLYMPHOID leukemia; CELL migration; TRANSFORMING growth factors; CADHERINS; CHEMOKINES; GENETIC regulation
- Publication
Nature Immunology, 2011, Vol 12, Issue 6, p485
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2029