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- Title
The ins and outs of cross-presentation.
- Authors
Rock, Kenneth L.
- Abstract
The principal mechanism by which the immune system eliminates tumors and viral infections is the cytotoxic T lymphocyte (CTL) response. However, when cells in tissues become infected or undergo malignant transformation, they are unable by themselves to alert the immune system to initiate a CTL response. Instead, bone marrow-derived antigen-presenting cells (APCs) that are billeted in tissues must acquire antigens from the affected sites, transport them to lymph nodes and then present them to naive CD8 T cells as peptides bound to major histocompatibility complex (MHC) class I molecules. APCs that carry out this immune surveillance function are dendritic cells and possibly macrophages. For tissue-tropic viruses that do not infect APCs and for tumors of parenchymal cells, the APC must acquire and present the antigens that are synthesized by the infected or tumor cell, a process that has been called 'cross-presentation.'
- Subjects
IMMUNE system; T cells; VIRUS diseases; ONCOLOGY; MAJOR histocompatibility complex
- Publication
Nature Immunology, 2003, Vol 4, Issue 10, p941
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1003-941