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- Title
Hexane extract of raw ginger enhances adipocyte differentiation through its PPARγ ligand activity on 3T3-L1 preadipocytes.
- Authors
Hideaki Kaneoka; Suguru Ito; Yuko Araki-Hashikawa; Takeo Yano; Katsuzumi Okumura; Norihiro Nishimura; Kazuhiro Kagotani
- Abstract
Ginger has been reported to show many health enhancement effects. We prepared a hexane extract of raw ginger (HRG) under low temperature, and examined its anti-obesity effects using 3T3-L1 cells. HRG promoted adipocyte differentiation in a dosedependent manner and enhanced the expression levels of adipocyte-specific genes, such as adiponectin and Glut4. HRG also exhibited peroxisome proliferator-activated receptor γ ligand activity, similar to antidiabetic drug thiazolidinediones, which promoted adipocyte differentiation and increased small adipocytes. In addition, HRG showed a tendency to suppress the action of tumor necrosis factor-α, which causes insulin resistance by downregulating the expression of adipocyte-specific genes. These findings suggest that HRG would be utilized as a functional food material for the prevention of obesity and related diseases by increasing small adipocytes.
- Subjects
GINGER; FAT cells; CELL differentiation; LIGANDS (Chemistry); ANTIOBESITY agents
- Publication
Japanese Journal of Food Chemistry & Safety, 2017, Vol 24, Issue 1, p16
- ISSN
1341-2094
- Publication type
Article