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- Title
Praćenje transmisivnih spongiformnih encefalopatija u Republici Hrvatskoj.
- Authors
Branović Čakanić, K.; Šoštarić, B.; Mihaljević, Ž.; Naletilić, Š.; Bilandžić, N.; Vlahović, D.; Bagarić, A.; Jungić, A.; Brnić, D.; Vretenar Špigelski, K.; Miškić, T.; Kiš, T.; Acinger Rogić, Ž.; Šeparović, S.
- Abstract
Transmissible spongiform encephalopathies are a group of rare and progressive neurodegenerative disorders that affect humans and animals. Transmissible spongiform encephalopathies are caused by a transmissible agent called a prion (proteinaceous infectious particle). Although these infections typically remain asymptomatic for a long time, the disease is always progressive with an inevitably lethal outcome. Transmissible spongiform encephalopathies include: classical and atypical bovine spongiform encephalopathy, classical and atypical scrapie in sheep and goats, chronic wasting disease, transmissible mink encephalopathy, feline spongiform encephalopathy, Creutzfeldt-Jakob disease, variant CreutzfeldtJakob disease, Gerstmann-Sträussler-Scheinker syndrome, Fatal familial insomnia, and kuru. Transmissible spongiform encephalopathy in sheep was first recognised almost three centuries ago and the disease was widely studied during the 20th century. The bovine spongiform encephalopathy epidemic in the United Kingdom in the mid-1980s prompted more extensive research, which led to the discovery that the causative agent of disease is a proteinaceous particle called a prion. A prion is a normal cellular protein found mostly on the surface on neurons and other cells throughout the body, but transforms to cause disease as the result of changes in the biochemical process during protein synthesis, though this process has been poorly understood. This article presents the results of monitoring of transmissible spongiform encephalopathies in Croatia from 2001 until the end of 2021. Systematic monitoring of bovine spongiform encephalopathy began in 2001, while monitoring for scrapie began in 2002. Until the end of 2021, 454,822 samples of bovine brain tissue were tested and no positives were found. In scrapie monitoring, 25,332 brain tissue samples were screened and no positives to classical scrapie were found, however four atypical scrapie cases in sheep were detected. Based on all implemented activities and bovine spongiform encephalopathy surveillance, the Republic of Croatia achieved the status of bovine spongiform encephalopathy negligible risk, the highest possible status according to the World Organization for Animal Health.
- Publication
Veterinarska Stanica, 2022, Vol 53, Issue 6, p709
- ISSN
0350-7149
- Publication type
Article
- DOI
10.46419/vs.53.6.6