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- Title
Kraniofaciální synostóza – Crouzonův syndrom.
- Authors
Husseini, Miriam El
- Abstract
Crouzon syndrome is a rare autosomal dominant disease due to mutation of genes encoding fibroblast growth factor receptor 2 (FGFR2). Premature closure of the cranial sutures causes a number of complications in growing children, such as increased intracranial pressure due to reduced intracranial space and growing brain tissue, epilepsy, hearing impairment, and optic nerve atrophy. The management of patients with Crouzon syndrome requires a multidisciplinary approach at specialized centers. Treatment is mainly surgical (remodulation of the skull) with very good prognosis.
- Subjects
FIBROBLAST growth factor receptors; FIBROBLAST growth factor 2; CRANIAL sutures; INTRACRANIAL pressure; OPTIC nerve; EPILEPSY
- Publication
Pediatrie pro Praxi, 2023, Vol 24, Issue 3, p194
- ISSN
1213-0494
- Publication type
Article
- DOI
10.36290/ped.2023.055