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- Title
Serum miR-224, miR-760, miR-483-5p, miR-378 and miR-375 as potential novel biomarkers in rheumatoid arthritis.
- Authors
Abdelaleem, Omayma O.; Fouad, Nermeen A.; Shaker, Olfat G.; Ahmed, Tarek I.; Abdelghaffar, Noha K.; Eid, Hanaa M.; Mohamed, Abdelrahmaan A.; Elebiary, Ahmed Magdy; Mohamed, Mohamed M.; Mahmoud, Rania H.; Magdy Elebiary, Ahmed
- Abstract
<bold>Background: </bold>Rheumatoid arthritis (RA) is an inflammatory autoimmune disease which affects various tissues and organs mainly joints. Serum microRNAs are considered a new class of non-coding RNA which plays a vital role in pathogenesis of RA.<bold>Methods: </bold>The current study was conducted on 80 RA patients and 80 healthy participants. Serum expression levels of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 were evaluated via real-time quantitative polymerase chain reaction (PCR).<bold>Results: </bold>Significant upregulation of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 was reported in the present study with respect to the control group (P = .031, P = .017, P = .026, P = .036 and P = .05, respectively). Furthermore, significant positive correlation between the abovementioned microRNAs with DAS28 score (P < .001, each) was demonstrated.<bold>Conclusion: </bold>Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA.
- Publication
International Journal of Clinical Practice, 2021, Vol 75, Issue 11, p1
- ISSN
1368-5031
- Publication type
journal article
- DOI
10.1111/ijcp.14651