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- Title
Potential mediators of improvement in painful chemotherapy-induced peripheral neuropathy via a web-based cognitive behavioural intervention.
- Authors
Knoerl, Robert; Barton, Debra L.; Holden, Janean E.; Krauss, John C.; LaVasseur, Beth; Smith, Ellen M. L.
- Abstract
Purpose: Preliminary evidence suggests that a self-guided cognitive and behaviourally-based pain management intervention (PROSPECT) is effective for chronic painful chemotherapy-induced peripheral neuropathy (CIPN), but its mechanism of action is unknown. The purpose of this secondary analysis was to explore if changes in anxiety, depression, sleep-related impairment, or fatigue mediated improvements in worst pain following PROSPECT in individuals with chronic painful CIPN. Methods: Sixty participants were randomized to receive self-guided cognitive behavioural pain management (access for eight weeks) or treatment as usual. A seven-day worst CIPN pain diary and the PROMIS measures of anxiety, depression, fatigue, and sleep-related impairment were administered pre/posttest (eight-weeks). Causal mediation analysis was used to quantify mediators of worst pain improvement. Results: None of the hypothesized mediators had a statistically significant effect on worst pain (n=38). Implications: Further research is needed to identify potential medi- ators of pain intensity that can be targeted by specific cognitive behavioural strategies to improve painful CIPN severity.
- Subjects
TREATMENT of peripheral neuropathy; CHRONIC pain; ANALYSIS of covariance; COGNITIVE therapy; MENTAL depression; FATIGUE (Physiology); LONGITUDINAL method; COMPUTERS in medicine; PERIPHERAL neuropathy; PROBABILITY theory; RESEARCH funding; SELF-evaluation; SLEEP disorders; THERAPEUTICS; PAIN management; SAMPLE size (Statistics); PILOT projects; SECONDARY analysis; PAIN measurement; ANXIETY disorders; RANDOMIZED controlled trials; TREATMENT effectiveness; PRE-tests &; post-tests; DATA analysis software; DIARY (Literary form); DESCRIPTIVE statistics; PREVENTION
- Publication
Canadian Oncology Nursing Journal, 2018, Vol 28, Issue 3, p178
- ISSN
1181-912X
- Publication type
Article
- DOI
10.5737/23688076283178183