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- Title
Lamivudine-Induced Skin Rash Remains an Underdiagnosed Entity in HIV: A Case Series from a Single Center.
- Authors
Sachdeva, Ravinder Kaur; Sharma, Aman; De, Dipankar; Malhi, Jasjit; Rewari, Bharat Bhushan; Singh, Surjit; Varma, Subhash
- Abstract
<bold>Background: </bold>Hypersensitivity reaction to antiretroviral treatment (ART) poses potential threats in maintenance of treatment. Lamivudine (3TC), is rare to cause rash. We are reporting 23 cases of 3TC-induced rash.<bold>Methods: </bold>An observational study conducted in the antiretroviral treatment center of a tertiary care hospital of North India from Feb 2009-Dec 2013 to record 3TC-induced rash. These were then recommended to start ART without 3TC and were followed up at 1-, 2-, and at 4-week intervals to monitor the toxicity, if any, with alternate therapy.<bold>Results: </bold>We observed 3TC-induced skin rash in 23 HIV-infected individuals (0.7%), out of 3213 HIV-infected individuals initiated on first line ART (zidovudine [ZDV]/tenofovir [TDF] + 3TC +nevirapine [NVP]/efavirenz [EFV] during the study period of 5 years [Feb 2009-Dec 2013]). The mean age of these 23 individuals was 37.5 ± 12.8 (17-60) years. Lamivudine rash was more common in women than men (F = 19, M = 4), with an overall mean age of 37.5 ± 12.8 (17-60) years. It was generalized, erythematous, maculopapular eruptions associated with intense itching with no associated mucosal involvement. Lamivudine was substituted with TDF in 19, didanosine (ddl) in 3 and abacavir (ABC) in 1 individual. Mean duration of follow-up is 11.1 ± 12.8 (3-42) months. CD4 count was repeated at 3 months and showed significant improvement (P = 0.002).<bold>Conclusion: </bold>Lamivudine-induced rash was found at a frequency of 0.7%. The correct and early recognition that the rash is due to 3TC, would save unnecessary substitution to a different class of drugs.
- Subjects
INDIA; LAMIVUDINE; SKIN infections; HIV-positive persons; ANTIRETROVIRAL agents; DIDANOSINE (Drug); CD4 antigen; DRUG side effects; EXANTHEMA; ANTI-HIV agents; THERAPEUTICS
- Publication
Journal of the International Association of Providers of AIDS Care, 2016, Vol 15, Issue 2, p153
- ISSN
2325-9582
- Publication type
journal article
- DOI
10.1177/2325957415599209