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- Title
TGF‐β: Master regulator of inflammation and fibrosis.
- Authors
Stewart, Alastair G.; Thomas, Belinda; Koff, Jon
- Abstract
The article offers information on the transforming growth factor-β (TGF-β) which is one of the three related gene products TGF-β 1–3 that activate the activin-like kinase receptor (ALK5), to elicit a bewildering array of physiological effects. It mentions that TGF-β gene polymorphism, is recognized as a modifier of variable disease phenotypes. It states that rise in TGF-β levels are associated with an accelerated decline in lung function in cystic fibrosis.
- Subjects
TRANSFORMING growth factors-beta; GENETIC polymorphisms; PHENOTYPES; CYSTIC fibrosis; ACTIVIN receptors
- Publication
Respirology, 2018, Vol 23, Issue 12, p1096
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.13415