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- Title
Calcifying pseudoneoplasms of the neuraxis (CAPNON). A case report.
- Authors
Li, Wei‐Qing; Wang, Shen‐Hao; Zhang, Zheng‐Wei; Chen, Jun; Li, Yi‐Ming; Lv, Ze‐Chao; Cao, Hao‐Tian; Ma, Xiao‐Mei; Liu, Hui‐Min; Zhu, Zhi
- Abstract
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, slow‐growing, benign lesions occurring throughout the neuroaxis that are frequently misdiagnosed and overlooked by clinicians. Here, we report a case of a 56‐year‐old woman who presented with a history of recurrent headache for the previous six years. Magnetic resonance imaging (MRI) revealed a 2.3‐cm‐sized solid mass in the right frontal lobe that was surrounded by marked edematous areas. The lesion demonstrated dense calcification and avid enhancement. The lesion was initially diagnosed as oligodendroglioma, and then found to be CAPNON based on histopathology of a surgically resected tissue. Genetic analysis revealed a nonsense mutation in the CUL4B gene. The patient's condition appeared to reflect a reactive, rather than neoplastic, process. Clinicians should be prepared to detect such pseudotumors histopathologically in order to avoid unnecessary differential tests of neoplastic or infectious diseases, as well as potentially harmful therapies.
- Subjects
MEDICAL personnel; NONSENSE mutation; MAGNETIC resonance imaging; GENETIC mutation; DIAGNOSIS; FRONTAL lobe
- Publication
Neuropathology, 2021, Vol 41, Issue 5, p371
- ISSN
0919-6544
- Publication type
Article
- DOI
10.1111/neup.12743