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- Title
Enhanced Aquaporin-4 immunoreactivity in sporadic Creutzfeldt-Jakob disease.
- Authors
Iwasaki, Yasushi; Mimuro, Maya; Yoshida, Mari; Hashizume, Yoshio; Ito, Masumi; Kitamoto, Tetsuyuki; Wakayama, Yoshihiro; Sobue, Gen
- Abstract
Aquaporin-4 (AQP-4) is a water channel protein located on the plasma membrane of astrocytes and is regulated under various conditions. In the present study, a series of brains with sporadic Creutzfeldt-Jakob disease (sCJD) were investigated to determine the possible contribution of AQP-4 in the development of sCJD pathology. Six cases of subacute spongiform encephalopathy (SSE) and four cases of panencephalopathic (PE)-type sCJD were included. Increased AQP-4 immunoreactivity compared to that in controls was observed in all sCJD patients, particularly in the cerebral neocortex and cerebellar cortex. AQP-4 immunoreactivity was present in the cell bodies and processes of protoplasmic astrocytes in SSE and around cell bodies and processes of hypertrophic astrocytes in PE-type sCJD. Analysis of serial sections showed the development of sCJD pathology, particularly in neocortical lesions, as follows: PrP deposition; spongiform change and gliosis; enhanced staining for AQP-4; hypertrophic astrocytosis; and neuronal loss and tissue rarefaction. Strong AQP-4 immunoreactivity was present in burnt-out lesions such as those of status spongiosus. These results indicate that increased AQP-4 expression in sCJD is an early pathologic event and appears to remain until the late disease stage. We suggest that increased expression of AQP-4 is a pathologic feature of sCJD.
- Subjects
AQUAPORINS; WATER-electrolyte balance (Physiology); ASTROCYTES; CREUTZFELDT-Jakob disease; BOVINE spongiform encephalopathy
- Publication
Neuropathology, 2007, Vol 27, Issue 4, p314
- ISSN
0919-6544
- Publication type
Article
- DOI
10.1111/j.1440-1789.2007.00781.x