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- Title
Autoimmune progesterone dermatitis: absence of contact sensitivity to glucocorticoids, oestrogen and 17-α-OH-progesterone.
- Authors
Stephens, C. J. M.; McFadden, J. P.; Black, M. M.; Rycroft, R. J. G.
- Abstract
Autoimmune progesterone dermatitis is a rare condition, characterized by recurrent premenstrual exacerbations of a dermatosis, in which sensitivity to progesterone can be demonstrated. The sensitizing mechanism is unknown. The aim of this study was to test the hypothesis that cross-sensitivity between steroid groups could induce allergy to endogenous progesterone in these patients. 5 patients with autoimmune progesterone dermatitis and 1 with oestrogen-sensitive dermatitis have been patch tested with a corticosteroid series, conjugated oestrogen 1% in petrolatum (pet.), and 17-α-OH-progesterone 2% pet. There were no immediate or delayed reactions at 2 and 4 days to any steroid group. We have therefore been unable to demonstrate steroid cross-sensitivity, or a use for 17-α-OH-progesterone in the investigation of oestrogen - and progesterone-sensitive dermatoses.
- Subjects
AUTOIMMUNE diseases; IMMUNOLOGIC diseases; AUTOIMMUNITY; DERMATOLOGY; SKIN diseases; SKIN inflammation
- Publication
Contact Dermatitis (01051873), 1994, Vol 31, Issue 2, p108
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/j.1600-0536.1994.tb01928.x