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- Title
Liquid–Liquid Phase Separation in Cardiovascular Diseases.
- Authors
Mo, Yuanxi; Feng, Yuliang; Huang, Wei; Tan, Ning; Li, Xinyi; Jie, Minwen; Feng, Tong; Jiang, Hao; Jiang, Lei
- Abstract
Liquid–liquid phase separation (LLPS) is a biochemical process in cells that can drive proteins, RNA, and other molecules to concentrate into droplets. These droplets do not have a lipid membrane but rather exist as distinct organelles relative to the surrounding environment, and act as biochemical reaction chambers. In recent years, significant progress has been made in the study of LLPS, especially in the neurodegenerative disease, cancer, and virology fields, but little is known about LLPS in cardiovascular disease (CVD). In this review, we discuss the current understanding of the mechanism and biological functions of LLPS, particularly its roles in regulating CVD.
- Subjects
PHASE separation; CARDIOVASCULAR diseases; MEMBRANE lipids; NEURODEGENERATION; ORGANELLES
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 19, p3040
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11193040