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- Title
Mitochondria and Doxorubicin-Induced Cardiomyopathy: A Complex Interplay.
- Authors
Schirone, Leonardo; D'Ambrosio, Luca; Forte, Maurizio; Genovese, Riccardo; Schiavon, Sonia; Spinosa, Giulia; Iacovone, Giuliano; Valenti, Valentina; Frati, Giacomo; Sciarretta, Sebastiano
- Abstract
Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer cause of death in DOX-treated patients. Although many different molecular mechanisms explaining the cardiac derangements induced by DOX were identified in past decades, the translation to clinical practice has remained elusive to date. This review examines the current understanding of DOX-induced cardiomyopathy (DCM) with a focus on mitochondria, which were increasingly proven to be crucial determinants of DOX-induced cytotoxicity. We discuss DCM pathophysiology and epidemiology and DOX-induced detrimental effects on mitochondrial function, dynamics, biogenesis, and autophagy. Lastly, we review the current perspectives to contrast the development of DCM, which is still a relatively diffused, invalidating, and life-threatening condition for cancer survivors.
- Subjects
CARDIOMYOPATHIES; MITOCHONDRIA; HEART failure; CARDIOTOXICITY; CANCER survivors
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 13, pN.PAG
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11132000