We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Oxysterols on Immune Cells and Related Diseases.
- Authors
de Freitas, Fábio Alessandro; Levy, Débora; Reichert, Cadiele Oliana; Cunha-Neto, Edecio; Kalil, Jorge; Bydlowski, Sérgio Paulo
- Abstract
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration to innate and humoral immune responses. In this regard, oxysterols have been involved in several diseases that have an immune component, from autoimmune and neurodegenerative diseases to inflammatory diseases, atherosclerosis, and cancer. Here, we review data on the participation of oxysterols, mainly 25-hydroxycholesterol and 7α,25-dihydroxycholesterol, in the immune system and related diseases. The effects of these oxysterols and main oxysterol receptors, LXR and EBI2, in cells of the immune system (B cells, T cells, macrophages, dendritic cells, oligodendrocytes, and astrocytes), and in immune-related diseases, such as neurodegenerative diseases, intestinal diseases, cancer, respiratory diseases, and atherosclerosis, are discussed.
- Subjects
OXYSTEROLS; IMMUNOLOGIC diseases; B cells; INTESTINAL diseases; CELL migration; DENDRITIC cells
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 8, p1251
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11081251