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- Title
Zinc-carnosine and vitamin E supplementation does not ameliorate gastrointestinal side effects associated with ciclosporin therapy of canine atopic dermatitis.
- Authors
Wilson, Laura S.; Rosenkrantz, Wayne S.; Roycroft, Linda M.
- Abstract
Chelated zinc-carnosine and vitamin E [GastriCalm (GCM); Teva Animal Health] is marketed as an anti-emetic supplement for dogs to assist the repair of damaged stomach and intestinal mucosa. The purpose of this prospective, double-blinded, placebo-controlled trial was to determine whether GCM reduced the frequency of vomiting, diarrhoea and appetite changes during initiation of ciclosporin (Atopica; Novartis Animal Health) therapy for the treatment of canine atopic dermatitis. Sixty privately owned dogs diagnosed with atopic dermatitis were randomly assigned to GCM ( n = 30) or placebo ( n = 30) groups. All dogs received ∼5 mg/kg ciclosporin (range, 3.5-5.8 mg/kg) once daily. Dogs <13.6 kg received half a tablet of GCM or placebo; dogs ≥13.6 kg received one tablet once daily. GastriCalm or placebo was administered 30 min prior to eating, and the ciclosporin was administered 2 h after feeding. Owners recorded episodes of vomiting, diarrhoea and appetite changes. Dogs were examined on days 0 and 14. Forty-one of 60 dogs (68.3%) had at least one episode of vomiting, diarrhoea or appetite change, leaving nine placebo dogs (30%) and ten GCM dogs (33.3%) free of adverse events (AE). Twenty-seven of 60 dogs (45%) vomited, and 15 of 60 (25%) had diarrhoea. There was no significant difference in episodes of individual AEs, but the placebo group had a significantly lower total AE score (summation of episodes of appetite change, vomiting and diarrhoea; P = 0.022). Small dogs (<6.82 kg) had significantly fewer total AEs in both treatment groups and tolerated ciclosporin better than larger dogs ( P < 0.05).
- Subjects
VITAMIN E in animal nutrition; CARNOSINE; DOG diseases; VETERINARY therapeutics; PLACEBOS; BLIND experiment; ATOPIC dermatitis treatment; DRUG efficacy; THERAPEUTICS
- Publication
Veterinary Dermatology, 2011, Vol 22, Issue 1, p53
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/j.1365-3164.2010.00910.x