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- Title
Lipo-prostaglandin E<sub>1</sub> in combination with steroid therapy is effective for treatment of sudden sensorineural hearing loss in Korean patients with Type 2 diabetes.
- Authors
Ahn, J. H.; Kim, T. Y.; Kim, Y.-J.; Han, M. W.; Yoon, T. H.; Chung, J. W.
- Abstract
Background Diabetes mellitus is a risk factor for sudden sensorineural hearing loss (SSNHL), possibly as a result of microvascular damage, increased blood viscosity and embolic and thrombotic episodes. Aim To perform a prospective, randomized clinical trial to determine the therapeutic effect of lipo-prostaglandin E1 (lipo-PGE1) on SSNHL in Korean patients with Type 2 diabetes. Methods The study group consisted of 270 consecutive Korean patients (130 male, 140 female) in whom SSNHL was diagnosed. Patients were classified as diabetic or non-diabetic by the new American Diabetes Association criteria. With the approval of the institute ethics committee, patients were randomly assigned to treatment with of 10 µg lipo-PGE1 (lipo-PGE1 group) given as a continuous infusion over 5 days, or saline (placebo group). In addition, all patients studied were treated with 48 mg methylprednisolone for 5 days. Results The overall recovery rates after treatment were 51.5% in diabetic and 64.2% in non-diabetic patients. In diabetic patients, there was a significantly higher rate of hearing improvement in the lipo-PGE1 group (64.7%) compared with the placebo group (37.5%), whereas, in non-diabetic patients, there was no significant difference in rate of hearing improvement between the lipo-PGE1 group (70.3%) and the placebo group (58.3%). Conclusion Lipo-PGE1 may have beneficial effects in the treatment of SSNHL in Korean patients with Type 2 diabetes.
- Subjects
KOREA; TYPE 2 diabetes; PROSTAGLANDIN E1; STEROID drugs; SENSORINEURAL hearing loss; PEOPLE with diabetes; THERAPEUTICS
- Publication
Diabetic Medicine, 2006, Vol 23, Issue 12, p1339
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2006.01993.x