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- Title
A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans.
- Authors
Varshney, Neha; Schaekel, Alida; Singha, Rima; Chakraborty, Tanmoy; van Wijlick, Lasse; Ernst, Joachim F.; Sanyal, Kaustuv
- Abstract
The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation.
- Subjects
CANDIDA albicans genetics; PROTEIN kinase genetics; CENTROMERE; FUNGAL genetics; CHROMOSOME segregation
- Publication
Genetics, 2015, Vol 199, Issue 3, p671
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.114.173542