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- Title
The Developmental Timing Regulator hbl-1 Modulates the Dauer Formation Decision in Caenorhabditis elegans.
- Authors
Karp, Xantha; Ambros, Victor
- Abstract
Animals developing in the wild encounter a range of environmental conditions, and so developmental mechanisms have evolved that can accommodate different environmental contingencies. Harsh environmental conditions cause Caenorhabditis elegans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereby indefinitely postponing L3 cell fates. HBL-1 is a key transcriptional regulator of L2 vs. L3 cell fate. Through the analysis of genetic interactions between mutations of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modulate the dauer formation decision in a complex manner. We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions.
- Subjects
CAENORHABDITIS elegans; GENETIC regulation; GENETIC mutation; GENETIC transcription; CYTOLOGY
- Publication
Genetics, 2011, Vol 187, Issue 1, p345
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.110.123992