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- Title
Autonomous and Programmable Strand Generator Implemented as DNA and Enzymatic Chemical Reaction Cascade.
- Authors
Kawamata, Ibuki; Nomura, Shin-ichiro M.; Murata, Satoshi
- Abstract
Nanomechanical devices are driven by chemical and/or physical signals, which exert their functions by transitioning between different molecular states. Many DNA-based nanomechanical devices proposed so far are typically driven by applying single-stranded DNAs representing instructions. To use these devices, it is necessary to manually deliver the strands in a step-by-step manner or use an external computerized apparatus to supply the strands. In this work, we propose an elaborate DNA reaction system capable of generating a sequence of multiple single-stranded DNAs according to a given program which is also a single-stranded DNA. The system is designed as a cascade of DNA hybridization and enzymatic reactions, in which the whole reaction is triggered by the program strand. The system can generate single-stranded DNAs one by one in a sequential order written on the program strand. We experimentally demonstrated the feasibility and the scalability of the system, by using the program strands encoding instruction sequences of different lengths.
- Subjects
NANOELECTROMECHANICAL systems; CHEMICAL reactions; DNA; NUCLEIC acid hybridization; SINGLE-stranded DNA
- Publication
New Generation Computing, 2022, Vol 40, Issue 2, p723
- ISSN
0288-3635
- Publication type
Article
- DOI
10.1007/s00354-022-00156-4