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- Title
Mechanisms of copper homeostasis in bacteria.
- Authors
Argüello, José M.; Raimunda, Daniel; Padilla-Benavides, Teresita
- Abstract
Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu+ transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures.
- Subjects
HOMEOSTASIS; COPPER proteins; OXIDATION-reduction reaction; CATALYTIC activity; REACTIVITY (Chemistry); MOLECULAR chaperones; BACTERIA
- Publication
Frontiers in Cellular & Infection Microbiology, 2013, Vol 3, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2013.00073