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- Title
Brown adipose tissue triglyceride content is associated with decreased insulin sensitivity, independently of age and obesity.
- Authors
Raiko, J.; Holstila, M.; Virtanen, K. A.; Orava, J.; Saunavaara, V.; Niemi, T.; Laine, J.; Taittonen, M.; Borra, R. J. H.; Nuutila, P.; Parkkola, R.
- Abstract
The aim of the present study was to determine whether single-voxel proton magnetic resonance spectroscopy ( 1H-MRS) can non-invasively assess triglyceride content in both supraclavicular fat depots and subcutaneous white adipose tissue ( WAT) to determine whether these measurements correlate to metabolic variables. A total of 25 healthy volunteers were studied using 18F-fluorodeoxyglucose positron emission tomography ( PET) and 15O-H2O PET perfusion during cold exposure, and 1H-MRS at ambient temperature. Image-guided biopsies were collected from nine volunteers. The supraclavicular triglyceride content determined by 1H-MRS varied between 60 and 91% [mean ± standard deviation (s.d.) 77 ± 10%]. It correlated positively with body mass index, waist circumference, subcutaneous and visceral fat masses and 8-year diabetes risk based on the Framingham risk score and inversely with HDL cholesterol and insulin sensitivity ( M-value; euglycaemic-hyperinsulinaemic clamp). Subcutaneous WAT had a significantly higher triglyceride content, 76-95% (mean ± s.d. 87 ± 5%; p = 0.0002). In conclusion, the triglyceride content in supraclavicular fat deposits measured by 1H-MRS may be an independent marker of whole-body insulin sensitivity, independent of brown adipose tissue metabolic activation.
- Subjects
BROWN adipose tissue; TRIGLYCERIDES; INSULIN resistance; OBESITY; PROTON magnetic resonance spectroscopy; WHITE adipose tissue
- Publication
Diabetes, Obesity & Metabolism, 2015, Vol 17, Issue 5, p516
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.12433