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- Title
Efficacy of enteric-coated mycophenolate sodium in patients with active lupus nephritis.
- Authors
SIU-KA MAK; KIN-YEE LO; MAN-WAI LO; SHUK-FAN CHAN; GENSY MW TONG; PING-NAM WONG; WONG, ANDREW K. M.
- Abstract
Background: The ideal treatment of lupus nephritis has yet to be defined. Both cyclophosphamide and mycophenolate mofetil have been used with encouraging results, but adverse events are frequently seen. There are no data on the use of enteric-coated mycophenolate sodium. Methods: We retrospectively reviewed 12 patients with active forms of lupus nephritis (1 class III, 7 class IV and 4 class V) treated with enteric-coated mycophenolate sodium combined with corticosteroids. Results: The mean age of the patients was 32.3 ± 11.2 years and the average length of follow up was 25.9 ± 8.9 months. The mean serum creatinine clearance was 93 ± 30.1 mL/min per 1.73 m2 and the mean proteinuria level was 4.5 ± 3.6 g/day. All had features that warranted aggressive treatment. Mycophenolate sodium was given for 12.9 ± 9.7 months with an averaged starting dose of 1350 ± 163 mg/day. Six patients attained complete remission and six attained partial remission with treatment. The mean interval to attain first remission (complete or partial) was 8.3 ± 5.7 weeks. At last follow up, all patients were in complete or partial remission. Apart from herpes zoster that developed in one patient, no other significant side-effects were encountered. Conclusion: Enteric-coated mycophenolate sodium was effective and well-tolerated in the treatment of active lupus nephritis.
- Subjects
ADRENOCORTICAL hormones; LUPUS nephritis; PROTEINURIA; CREATININE; HERPES zoster; DISEASE remission; THERAPEUTIC complications; PATIENTS; THERAPEUTICS
- Publication
Nephrology, 2008, Vol 13, Issue 4, p331
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/j.1440-1797.2007.00862.x