We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Meta-analysis: ertapenem for complicated intra-abdominal infections.
- Authors
FALAGAS, M. E.; PEPPAS, G.; MAKRIS, G. C.; KARAGEORGOPOULOS, D. E.; MATTHAIOU, D. K.
- Abstract
Background Ertapenem is a new member of the carbapenem class of antibiotics, with a favourable pharmacokinetic profile, but a narrower spectrum of antimicrobial activity, compared with older representatives of this class. Aim To evaluate the effectiveness and safety of ertapenem for treatment of complicated intra-abdominal infections. Methods We performed a meta-analysis of randomized-controlled trials identified in PubMed, Cochrane and Scopus that compared ertapenem with other antimicrobial regimens, in patients of all ages, with complicated intra-abdominal infections. The primary outcomes evaluated were clinical success (cure or improvement) in the modified intention-to-treat population and clinical adverse events. Results Six randomized-controlled trials involving patients with complicated intra-abdominal infections, mainly of mild-to-moderate severity (three with a double-blind design; one performed in children) that compared ertapenem treatment (once daily) against piperacillin/tazobactam, ceftriaxone plus metronidazole and ticarcillin/clavulanic acid (in three, two and one randomized-controlled trials respectively) were included. No difference was found between adult patients with complicated intra-abdominal infections treated with ertapenem vs. comparators, regarding clinical success (five randomized-controlled trials, 2002 patients, fixed-effect model, odds ratio: 1.11, 95% confidence interval (CI): 0.89–1.39); clinical adverse events (four randomized-controlled trials, 1530 patients, fixed-effect model, OR: 0.86, 95% CI: 0.61–1.20); microbiological success; mortality and withdrawals because of adverse events. Ertapenem was associated with more laboratory adverse events (four randomized-controlled trials, 1530 patients, fixed-effect model, OR: 1.73, 95% CI: 1.14–2.61), but none was reported as serious. Conclusion This meta-analysis provides additional evidence that ertapenem can be used as effectively and safely, as other recommended antimicrobial regimens, for the treatment of complicated intra-abdominal infections, particularly of mild-to-moderate severity.
- Subjects
INFECTION; ABDOMINAL diseases; ANTI-infective agents; ANTIBACTERIAL agents; CLINICAL competence; META-analysis
- Publication
Alimentary Pharmacology & Therapeutics, 2008, Vol 27, Issue 10, p919
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2008.03642.x