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- Title
Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model.
- Authors
XIAOJUAN MA; XIUMIN MA; ZHIXING MA; JING WANG; ZHAN SUN; WENYAN YU; FENGSEN LI; JIANBING DING
- Abstract
The Uygur herb, Hyssopus officinalis L., has been demonstrated to affect the levels of a number of cytokines in asthmatic mice, including interleukin-4, -6 and -17 and interferon-γ. In the present study, the effect of Hyssopus officinalis L. on ai rway immune regulat ion and ai rway inflammat ion was investigated in a mouse model of chronic asthma. A total of 32 BALB/c mice were randomly divided into four groups, which included the normal, chronic asthmatic, dexamethasone treatment and Hyssopus officinalis L. treatment groups. Mice were sensitized and challenged with ovalbumin to establish an asthma model and the ratio of eosinophils (EOS) in the bronchoalveolar lavage fluid (BALF) was determined. In addition, the levels of immunoglobulin (Ig)E and IgG were detected using an enzyme-linked immunosorbent assay. The degree of airway mucus secretion was observed using the periodic acid-Schiff stain method. The results demonstrated that the ratio of EOS in the BALF and the level of serum IgE in the chronic asthmatic and dexamethasone treatment groups increased, while the level of serum IgG decreased, when compared with the normal group. In addition, excessive secretion of airway mucus was observed in these two groups. However, the EOS ratio in the BALF and the levels of serum IgE and IgG in the Hyssopus officinalis L. treatment group were similar to the results observed in the normal group. In conclusion, Hyssopus officinalis L. not only plays an anti-inflammatory role by inhibiting the invasion of EOS and decreasing the levels of IgE, but also affects immune regulation.
- Subjects
HYSSOPUS officinalis; ALTERNATIVE treatment for asthma; AIRWAY (Anatomy); IMMUNOREGULATION; EOSINOPHILS; BRONCHOALVEOLAR lavage; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; DISEASES
- Publication
Experimental & Therapeutic Medicine, 2014, Vol 8, Issue 5, p1371
- ISSN
1792-0981
- Publication type
Article
- DOI
10.3892/etm.2014.1978