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- Title
Genome-wide association studies in pediatric chronic kidney disease.
- Authors
Gupta, Jayanta; Kanetsky, Peter; Wuttke, Matthias; Köttgen, Anna; Schaefer, Franz; Wong, Craig
- Abstract
The genome-wide association study (GWAS) has become an established scientific method that provides an unbiased screen for genetic loci potentially associated with phenotypes of clinical interest, such as chronic kidney disease (CKD). Thus, GWAS provides opportunities to gain new perspectives regarding the genetic architecture of CKD progression by identifying new candidate genes and targets for intervention. As such, it has become an important arm of translational science providing a complementary line of investigation to identify novel therapeutics to treat CKD. In this review, we describe the method and the challenges of performing GWAS in the pediatric CKD population. We also provide an overview of successful GWAS for kidney disease, and we discuss the established pediatric CKD cohorts in North America and Europe that are poised to identify genetic risk variants associated with CKD progression.
- Subjects
GENETICS of disease susceptibility; CHRONIC kidney failure; CHRONIC kidney failure in children; GENE expression; GENES; GENETIC mutation; PHENOTYPES; GENOMICS; DISEASE progression
- Publication
Pediatric Nephrology, 2016, Vol 31, Issue 8, p1241
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-015-3235-y