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- Title
Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort.
- Authors
Kumar, Juhi; McDermott, Kelly; Abraham, Alison; Friedman, Lisa; Johnson, Valerie; Kaskel, Frederick; Furth, Susan; Warady, Bradley; Portale, Anthony; Melamed, Michal
- Abstract
Background: Vitamin D plays an important role in the mineral and bone disorder seen in chronic kidney disease (CKD). Deficiency of 25-hydroxyvitamin D (25OHD) is highly prevalent in the adult CKD population. Methods: The prevalence and determinants of 25OHD deficiency (defined as a level <20 ng/ml) were examined longitudinally in 506 children in the CKiD cohort. Predictors of secondary hyperparathyroidism and the determinants of 1,25-dihydroxyvitamin D (1,25(OH)D) levels were also evaluated. Results: Deficiency of 25OHD was observed in 28 % of the cohort at enrollment. Significant predictors of 25OHD deficiency were older age, non-white race, higher body mass index, assessment during winter, less often than daily milk intake, non-use of nutritional vitamin D supplement and proteinuria. Lower values of glomerular filtration rate (GFR), serum 25OHD, calcium and higher levels of FGF23 were significant determinants of secondary hyperparathyroidism. Lower GFR, low serum 25OHD, nephrotic-range proteinuria, and high FGF23 levels were significant determinants of serum 1,25(OH) D levels. Conclusions: Deficiency of 25OHD is prevalent in children with CKD and is associated with potentially modifiable risk factors such as milk intake, nutritional vitamin D supplement use, and proteinuria. 25OHD deficiency is a risk factor for secondary hyperparathyroidism and decreased serum 1,25(OH)D in children with CKD.
- Subjects
NORTH America; CHRONIC kidney failure complications; CHI-squared test; CONFIDENCE intervals; LONGITUDINAL method; MEDICAL cooperation; PARATHYROID hormone; PEDIATRICS; QUESTIONNAIRES; REGRESSION analysis; RESEARCH; RESEARCH funding; STATISTICS; VITAMIN D; VITAMIN D deficiency; DATA analysis; DISEASE prevalence; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio
- Publication
Pediatric Nephrology, 2016, Vol 31, Issue 1, p121
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-015-3190-7