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- Title
Brighter spotty lesions on spinal MRI help differentiate AQP4 antibody-positive NMOSD from MOGAD.
- Authors
Hyun, Jae-Won; Lee, Hye Lim; Park, Jaehong; Kim, Jiah; Min, Ju-Hong; Kim, Byoung Joon; Kim, Seung Woo; Shin, Ha Young; Huh, So-Young; Kim, Woojun; Seo, Ji Won; Kim, Ki Hoon; Kim, Su-Hyun; Kim, Ho Jin
- Abstract
In a large acute myelitis cohort, we aimed to determine whether brighter spotty lesions (BSLs)—using the refined terminology—on spinal magnetic resonance imaging (MRI) help distinguish aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) from myelin oligodendrocyte glycoprotein antibody disease (MOGAD). An experienced neuro-radiologist and two neurologists independently analyzed 133 spinal MRI scans (65 from MOGAD and 68 from AQP4-NMOSD) acquired within 1 month of attacks. BSLs were observed in 18 of 61 (30%) participants with AQP4-NMOSD, while none of 49 participants with MOGAD showed BSL (p < 0.001). BSL during the acute phase would be useful to differentiate AQP4-NMOSD from MOGAD.
- Subjects
MYELIN oligodendrocyte glycoprotein; MYELITIS; MAGNETIC resonance imaging; NEUROMYELITIS optica; AQUAPORINS
- Publication
Multiple Sclerosis Journal, 2022, Vol 28, Issue 6, p989
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585211060326