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- Title
Multiple drugs as inducing or exacerbating agents in subacute cutaneous lupus erythematosus.
- Authors
Margheim, Ashlee; Schadt, Courtney R.; Callen, Jeffrey P.
- Abstract
The first patient had a history of DI-SCLE attributed to HCTZ, golimumab, and esomeprazole prior to developing disease linked to amlodipine. Dear Editor, Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) was first described in five patients taking hydrochlorothiazide (HCTZ) by Reed I et al i . in 1985.1 More than three decades later, over 100 agents have been linked to this distinct subtype of cutaneous lupus erythematosus, with approximately 20% of newly diagnosed cases of SCLE thought to be drug-induced or drug-exacerbated.2 SCLE presents clinically as annular plaques or papulosquamous lesions in a photodistribution, and most patients have anti-Ro/SSA antibodies.3 With the exception of cross-reactivity of proton pump inhibitors, SCLE recurrence following exposure to drugs of different classes has rarely been reported.
- Subjects
LUPUS erythematosus; SYSTEMIC lupus erythematosus; DRUGS
- Publication
International Journal of Dermatology, 2021, Vol 60, Issue 5, p643
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.15290