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- Title
Efficient Synthesis of 2-Aminoquinazoline Derivatives via Acid-Mediated [4+2] Annulation of N -Benzyl Cyanamides.
- Authors
Qin, Zhao-Yi; Sun, Chen-Xi; Zhang, Wen-Wen; Li, Jun-Ru; Gong, Yin-Xiang; Shu, Wen-Ming; Wu, An-Xin
- Abstract
The synthesis of 2-aminoquinazoline derivatives is achieved by using hydrochloric acid as a mediator in the [4+2] annulation reaction between N-benzyl cyanamides and 2-amino aryl ketones. In addition, 2-amino-4-iminoquinazolines are synthesized by the reaction of 2-aminobenzonitriles, instead of 2-amino aryl ketones, with N-benzyl cyanamides. A wide range of substrates can be used and high yields are obtained, demonstrating the practicality of this method for the synthesis of 2-aminoquinazoline derivatives.
- Subjects
CALCIUM cyanamide; ANNULATION; HYDROCHLORIC acid
- Publication
Catalysts (2073-4344), 2023, Vol 13, Issue 11, p1447
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal13111447