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- Title
Gut microbe and hepatic macrophage polarization in non-alcoholic fatty liver disease.
- Authors
Yao Chen; Yumeng Gan; Huijie Zhong; Yincong Liu; Jingdi Huang; Wenxue Wang; Jiawei Geng
- Abstract
Non-alcoholic fatty liver disease (NAFLD) is a common chronic hepatic disorder with the potential to progress to hepatic fibrosis, hepatic cirrhosis, and even hepatocellular carcinoma. Activation of hepatic macrophages, important innate immune cells predominantly composed of Kupffer cells, plays a pivotal role in NAFLD initiation and progression. Recent findings have underscored the regulatory role of microbes in both local and distal immune responses, including in the liver, emphasizing their contribution to NAFLD initiation and progression. Key studies have further revealed that gut microbes can penetrate the intestinal mucosa and translocate to the liver, thereby directly influencing hepatic macrophage polarization and NAFLD progression. In this review, we discuss recent evidence regarding the translocation of intestinal microbes into the liver, as well as their impact on hepatic macrophage polarization and associated cellular and molecular signaling pathways. Additionally, we summarize the potential mechanisms by which translocated microbes may activate hepatic macrophages and accelerate NAFLD progression.
- Subjects
NON-alcoholic fatty liver disease; HEPATITIS B virus; KUPFFER cells; HEPATIC fibrosis; MACROPHAGES; CIRRHOSIS of the liver; PLANT translocation
- Publication
Frontiers in Microbiology, 2023, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2023.1285473