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- Title
Prophages in Salmonella enterica: a driving force in reshaping the genome and physiology of their bacterial host?
- Authors
Wahl, Astrid; Battesti, Aurélia; Ansaldi, Mireille
- Abstract
Summary: Thanks to the exponentially increasing number of publicly available bacterial genome sequences, one can now estimate the important contribution of integrated viral sequences to the diversity of bacterial genomes. Indeed, temperate bacteriophages are able to stably integrate the genome of their host through site‐specific recombination and transmit vertically to the host siblings. Lysogenic conversion has been long acknowledged to provide additional functions to the host, and particularly to bacterial pathogen genomes where prophages contribute important virulence factors. This review aims particularly at highlighting the current knowledge and questions about lysogeny in Salmonella genomes where functional prophages are abundant, and where genetic interactions between host and prophages are of particular importance for human health considerations. Salmonella enterica genomes, as most other bacterial species, host multiple prophages whose genes can represent up to 5% of the genome content. In this review, we aim at putting into light the multiple genetic interactions that can be weaved between the host and its prophages and between prophages themselves within the host.
- Subjects
SALMONELLA enterica; NUCLEOTIDE sequencing; LYSOGENY; VIRULENCE of bacteria; BACTERIOPHAGES
- Publication
Molecular Microbiology, 2019, Vol 111, Issue 2, p303
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/mmi.14167