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- Title
Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation.
- Authors
Reiner, Martin F.; Bertschi, Daniela A.; Werlen, Laura; Wiencierz, Andrea; Aeschbacher, Stefanie; Lee, Pratintip; Rodondi, Nicolas; Moutzouri, Elisavet; Bonati, Leo; Reichlin, Tobias; Moschovitis, Giorgio; Rutishauser, Jonas; Kühne, Michael; Osswald, Stefan; Conen, David; Beer, Jürg H.
- Abstract
Omega-3 fatty acids (n-3 FAs) are associated with a lower risk of ischemic stroke in patients with atrial fibrillation (AF). Antithrombotic mechanisms may in part explain this observation. Therefore, we examined the association of n-3 FAs with D-dimer and beta-thromboglobulin (BTG), markers for activated coagulation and platelets, respectively. The n-3 FAs eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA) were determined via gas chromatography in the whole blood of 2373 patients with AF from the Swiss Atrial Fibrillation cohort study (ClinicalTrials.gov Identifier: NCT02105844). In a cross-sectional analysis, we examined the association of total n-3 FAs (EPA + DHA + DPA + ALA) and the association of individual fatty acids with D-dimer in patients with detectable D-dimer values (n = 1096) as well as with BTG (n = 2371) using multiple linear regression models adjusted for confounders. Median D-dimer and BTG levels were 0.340 ug/mL and 448 ng/mL, respectively. Higher total n-3 FAs correlated with lower D-dimer levels (coefficient 0.94, 95% confidence interval (Cl) 0.90–0.98, p = 0.004) and lower BTG levels (coefficient 0.97, Cl 0.95–0.99, p = 0.003). Likewise, the individual n-3 FAs EPA, DHA, DPA and ALA showed an inverse association with D-dimer. Higher levels of DHA, DPA and ALA correlated with lower BTG levels, whereas EPA showed a positive association with BTG. In patients with AF, higher levels of n-3 FAs were associated with lower levels of D-dimer and BTG, markers for activated coagulation and platelets, respectively. These findings suggest that n-3 FAs may exert antithrombotic properties in patients with AF.
- Subjects
ATRIAL fibrillation diagnosis; BIOMARKERS; DOCOSAHEXAENOIC acid; ALPHA-linolenic acid; CONFIDENCE intervals; CROSS-sectional method; MULTIPLE regression analysis; BETA globulins; EICOSAPENTAENOIC acid; GAS chromatography; OMEGA-3 fatty acids; DESCRIPTIVE statistics; RESEARCH funding; FIBRIN fibrinogen degradation products
- Publication
Nutrients, 2024, Vol 16, Issue 2, p178
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16020178