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- Title
Ethanol Extract of Liriope platyphylla Root Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice via Regulation of Lipogenesis and Lipid Uptake.
- Authors
Le, Trang Nu Huyen; Choi, Ho-Jung; Jun, Hee-Sook
- Abstract
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder that causes excess lipid accumulation in the liver and is the leading cause of end-stage liver disease. Liriope platyphylla is a medicinal herb that has long been used to treat cough, obesity, and diabetes. However, the effect of Liriope platyphylla on NAFLD has not been studied. The aim of this study was to investigate the effect of Liriope platyphylla root ethanolic extract (LPE) on hepatic lipid accumulation in high-fat diet (HFD)-induced obese mice. Six-week-old C57BL/6 male mice were fed a HFD for 8 weeks and then treated with LPE (100 or 250 mg/kg/day) by oral gavage for another 8 weeks. Body weight gain and liver weight were significantly lower in the 250 mg/kg LPE-treated HFD group than in the vehicle-treated HFD group. Histological analysis of liver sections demonstrated that LPE treatment reduced lipid accumulation compared to the vehicle treatment. The serum total cholesterol, AST, and ALT levels significantly decreased in the LPE-treated HFD group compared to those in the vehicle-treated HFD group. The LPE significantly decreases the protein expression levels of SREBP1, ACC, p-ACC, FAS, and SCD1, which are involved in lipogenesis, and PPARγ, CD36/FAT, and FATP5, which are involved in fatty acid uptake, both in vivo and in vitro. Thus, LPE may attenuate HFD-induced NAFLD by decreasing lipid accumulation by inhibiting lipogenesis and fatty acid uptake.
- Subjects
OBESITY risk factors; LIPID metabolism; PROTEIN metabolism; IN vitro studies; PROTEINS; FAT content of food; MEDICINAL plants; BODY weight; IN vivo studies; FATTY liver; ANIMAL experimentation; LIVER; PEROXISOME proliferator-activated receptors; PLANT roots; WEIGHT gain; DNA-binding proteins; PLANT extracts; HISTOLOGY; LIPIDS; MICE; CHOLESTEROL; ASPARTATE aminotransferase; ALANINE aminotransferase
- Publication
Nutrients, 2021, Vol 13, Issue 10, p3338
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13103338