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- Title
Interrelation between Plasma Concentrations of Vitamins C and E along the Trajectory of Ageing in Consideration of Lifestyle and Body Composition: A Longitudinal Study over Two Decades.
- Authors
Jungert, Alexandra; Neuhäuser-Berthold, Monika
- Abstract
Although the interrelation between vitamins C and E has been demonstrated on an experimental level, its impact on biomarkers in community-dwelling subjects along the trajectory of ageing has not yet been shown. The present longitudinal study investigates the determinants and interrelation of vitamins C and E plasma concentrations in 399 subjects aged ≥60 years with a median follow-up time of 12 years. Linear mixed-effects models were used to analyze the influence of age, sex, body composition, dietary intake, physical activity, smoking and supplement/drug use on plasma vitamin C, plasma α-tocopherol and α-tocopherol/total cholesterol ratio. At baseline, median plasma concentrations of vitamin C and α-tocopherol were 74 and 35 µmol/L. Absolute fat-free mass, physical activity, use of supplements, and plasma α-tocopherol were main determinants of plasma vitamin C in the course of ageing. For the α-tocopherol/total cholesterol ratio, age, use of supplements, use of lipid-modifying drugs, and plasma vitamin C were main determinants. The results reveal a stable positive interrelation between plasma concentrations of vitamins C and E along the trajectory of ageing independent of the other identified determinants. The possible regulatory mechanisms that could explain this robust positive interrelation remain to be elucidated.
- Subjects
AGE distribution; AGING; BODY composition; CHOLESTEROL; DIETARY supplements; INGESTION; LONGITUDINAL method; SEX distribution; SMOKING; TIME; VITAMIN C; VITAMIN E; LIFESTYLES; LEAN body mass; PHYSICAL activity; MIDDLE age; OLD age
- Publication
Nutrients, 2020, Vol 12, Issue 10, p2944
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12102944