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- Title
Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease.
- Authors
Cansanção, Kátia; Silva Monteiro, Luana; Carvalho Leite, Nathalie; Dávalos, Alberto; Tavares do Carmo, Maria das Graças; Arantes Ferreira Peres, Wilza
- Abstract
Changes in lipid metabolism occur during the development and progression non-alcoholic fatty liver disease (NAFLD). However, the fatty acid (FA) profile in red blood cells (RBC) from patients with liver fibrosis remains unexplored. Thus, the goal of this study was to evaluate the fatty acid profile in RBC, dietary lipid intake and insulin resistance indicators in patients with NAFLD, according to the degree of hepatic fibrosis. Using elastography, patients were classified with (n = 52) and without (n = 37) advanced liver fibrosis. The fatty acid profile in RBC was analyzed using gas chromatography and the lipid intake was evaluated through a 24-h dietary recall. Subjects with advanced liver fibrosis had higher levels of palmitic, stearic and oleic acid and total monounsaturated fatty acid (MUFA) and insulin (p < 0.05), and lower levels of elongase very long chain fatty acids protein-6 and the delta-5-desaturase enzymatic activity (p < 0.05). These results suggest a lack of regulation of enzymes related to FA metabolism in patients with advanced fibrosis.
- Subjects
FATTY acids; FATTY liver; GAS chromatography; INGESTION; INSULIN; INSULIN resistance; LIPIDS; CIRRHOSIS of the liver; ULTRASONIC imaging; UNSATURATED fatty acids; DISEASE complications; DIAGNOSIS
- Publication
Nutrients, 2018, Vol 10, Issue 11, p1586
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10111586