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- Title
Research on the pathogenesis of Alzheimer's disease based on thalamocortical computational model.
- Authors
Yijin Gang; Tao Li; Xianjing Xu; Qi Zheng; Weiping Wang
- Abstract
Alpha rhythm slowing is an important electroencephalogram(EEG) feature associated with (AD). This study aims to understand the correlation between alpha band deceleration and molecular changes from the perspective of neural computing. Considering the effect of Aβ amyloid deposition on the inhibitory changes in the thalamic, a thalamic cortical model coupled with Aβ amyloid is established. The results show that Aβ amyloid deposition may induce neurotoxicity in thalamic reticular nucleus neurons, which results in inhibitory changes in the thalamus and slows the alpha rhythm of EEG output from the thalamus. In order to understand the pathogenesis more intuitively, some numerical simulations are provided to illustrate the obtained theories. This research is helpful to understand the pathogenesis of AD, so as to provide theoretical basis for the intervention and control of the disease.
- Subjects
ALZHEIMER'S disease; ALPHA rhythm; THALAMIC nuclei; PATHOGENESIS; AMYLOID; CEREBRAL amyloid angiopathy
- Publication
Frontiers in Neurology, 2024, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2024.1353305