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- Title
H γλυκοζυλιωμένη αιμοσφαιρίνη στην πρόληψη, στη διάγνωση και στη ρύθμιση του σακχαρώδους διαβήτη Σύγχρονα δεδομένα.
- Authors
Καββαδά, Α.; Καββαδάς, Δ.; Ιντζές, Γ.; Χατζηδημητρίου, Μ.; Παπαμήτσου, Θ.
- Abstract
Diabetes mellitus (DM) is a metabolic syndrome that has direct consequences on health, shapes the daily life of the patient, and causes susceptibility to many pathological conditions. Its timely diagnosis and regulation are therefore imperative. In this endeavor, two key biochemical indicators are glucose and glycosylated hemoglobin (HbA1c), the increase in which is due to dysfunction and or lack of insulin. HbA1c is a glycoprotein that is normally present in very small amounts in the blood, but it increases significantly in patients with DM. A variety of laboratory methods are used for measuring the blood level of HbA1c, including HPLC-mass spectrometry and HPLC-capillary electrophoresis, and easy-to-use automated systems are available. Applications of HbA1c measurement include the control of DM, and especially of type 2, and with the development of laboratory techniques, it is now considered a very sensitive diagnostic indicator. International organizations have unanimously set the diagnostic threshold at 6.5%, but levels of HbA1c that approach, but do not exceed, the diagnostic point are affected by many individual factors (e.g., age, nationality, individual history), which makes definition of international guidelines difficult.
- Subjects
GLYCOSYLATED hemoglobin; DIABETES; METABOLIC syndrome; LABORATORY techniques; INTERNATIONAL agencies
- Publication
Archives of Hellenic Medicine / Arheia Ellenikes Iatrikes, 2022, Vol 39, Issue 1, p45
- ISSN
1105-3992
- Publication type
Article