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- Title
Investigation of Apelin Level and Oxidative Damage in Children Diagnosed with Epilepsy for the First Time.
- Authors
AKSU, Vedat; ÖZGÖÇER, Tuba; ÇELİK, Hakim; ÇALIK, Mustafa
- Abstract
Background: Epilepsy disease, which negatively affects 65 million people around the world, can be seen in all age groups regardless of gender. Disease is known throughout the history of human disease, although the mechanism is still unknown. In this study, it is aimed to investigate of apelin and oxidative stress levels in children with epilepsy. Materials and Methods: Children with epilepsy (aged 0-16) who had been diagnosed with epilepsy and did not start treatment were included in the study. This study included control group healthy normal children (n=28) and children with epilepsy group (n=28), totally 56 children were included. Blood samples were removed for apelin, advanced protein oxidation product (AOPP) and DNA damage marker 8-Hydroxy 2-Deoxyguanosine (8-OHdG) levels analyses by ELISA method. Results: Apelin level in generalized type epilepsy was lower than the control group and the complicated febrile group (p<0.05). It has been found that the number of epilepsy seizures is more common in the generalized type epilepsy (p<0.05). While the number of seizures decreased due to the increase in apelin (p=0.05; r=-0.260), it increased due to the increase in AOPP (p=0.05; r=0.264). AOPP was higher in focal type epilepsy than control group. Conclusions: Consequently; 1) Apelin reduced the number of seizures by preventing oxidative DNA damage, 2) Increased the number of seizures by the AOPP increase, 3) As the age rises, the number of seizures has been determined to lower due to decreased in AOPP level.
- Subjects
PROTEINS; GROWTH factors; EPILEPSY; DEOXYRIBONUCLEOSIDES; OXIDATIVE stress; COMPARATIVE studies; DESCRIPTIVE statistics; ENZYME-linked immunosorbent assay; DNA damage; SEIZURES (Medicine); PEPTIDES; DISEASE complications; CHILDREN
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2021, Vol 18, Issue 3, p493
- ISSN
1304-9623
- Publication type
Article
- DOI
10.35440/hutfd.1006598