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- Title
Mannose-Binding Lectin Serum Levels in Patients With Candiduria.
- Authors
Moslem, Maryam; Mahmoudabadi, Ali Zarei; Fatahinia, Mahnaz; Kheradmand, Alireza
- Abstract
Background: Candida species are normal mycoflora of human body which are capable to cause urinary tract infection (UTI). Mannose-binding lectin (MBL) is a kind of innate immune system and decreasing plasma levels of MBL may disrupt the natural immune response and increase susceptibility to infections. Objectives: The aim of the present study was to assess MBL in the serum of patients with candiduria and compare them with control. Patients and Methods: The blood and urine samples were collected from 335 patients (hospitalized in Golestan hospital, Ahvaz) using standard methods and the growing colonies on CHROMagar were identified using routine diagnostic tests. MBL activity in the serum of patients with candiduria and 45 controls was measured using Eastbiopharm enzyme-linked immunosorbent assay (ELISA) kit. Results: In this study, 45 (13.4 %) urine samples were positive for Candida species (17 males and 28 females). The most common isolated yeast was Candida albicans (34%), followed by C. glabrata (32.1%), C. tropicalis (9.4%), other Candida species (22.6%), and Rhodotorula species (1.9%). The mean serum levels of MBL were 0.85 ± 0.01 ng/mL and 1.02 ± 0.03 ng/mL among candiduric patients and controls, respectively, and there was no significant difference between the two groups (P = 0.6). Conclusions: Our results showed that there was no significant relationship between MBL serum levels and candiduria.
- Subjects
URINARY tract infections; CANDIDA; MANNOSE-binding lectins; BLOOD serum analysis; NATURAL immunity; URINALYSIS; PATIENTS
- Publication
Jundishapur Journal of Microbiology, 2015, Vol 8, Issue 12, p1
- ISSN
2008-3645
- Publication type
Article
- DOI
10.5812/jjm.29491