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- Title
Long‐term clinical outcomes of patients with hematologically unexplained cytopenia after routine assessment: A single center study.
- Authors
Johansen, Morten Munk; Andersen, Michael Asger; Grønbæk, Kirsten; Hansen, Jakob Werner
- Abstract
Objective: We investigated mortality and long‐term development of malignant hematological disease, cancer, liver‐, renal‐, and rheumatic disease in patients with unexplained cytopenia (UC). Methods: We screened all patients referred to the outpatient clinic at the Department of Hematology, Rigshospitalet, Copenhagen, with a suspected myeloid neoplasm from June 2009 to the end of 2012. Through registry linkage, we obtained information on hospital‐based ICD‐10 diagnoses and survival. We estimated cumulative incidences of disease and hazard ratios of all‐cause mortality using the Aalen‐Johansen estimator and Cox regression. We compared incidences and mortality with a control cohort. Results: Among 1820 referrals, 221 had UC. The UC group had a 5‐year cumulative incidence of malignant hematological disease of 8.91% (CI 95%: 4.98‐12.84) compared to 0.93(CI 95%: 0.32‐1.55) in the matched controls. In addition, UC patients had higher incidences of cancer, liver, and rheumatic disease. Mortality was higher in UC patients compared to the matched controls with a HR of 1.43 [P = 0.038, CI 95%: 1.02‐2.00] adjusted for comorbidity, sex, and age. Most of the mortality and morbidity were ascribed to patients 50 years or older. Conclusions: Unexplained cytopenia patients had a higher incidence of malignant hematological‐, cancer‐, liver‐, and rheumatic disease and increased mortality compared to the general population.
- Subjects
HEMATOLOGIC malignancies; CANCER; RHEUMATISM; MORTALITY; COLLAGEN diseases
- Publication
European Journal of Haematology, 2018, Vol 101, Issue 5, p595
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13146