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- Title
ELECTRONIC WASTE INDUCED DNA DAMAGE: A REVIEW.
- Authors
Alabi, Okunola A.; Bakare, Adekunle A.
- Abstract
Electronic waste (e-waste) has become a global environmental and public health issue due to its high production volume and inadequate management practices in many countries. E-waste contains hazardous substances including persistent organic pollutants and heavy metals which when inappropriately recycled or processed can result in environmental contamination by these toxicants. Exposure to these components arises through dermal contact, ingestion, and inhalation. One of the major health concerns is the DNA damaging potential of e-waste in exposed plants and animals, especially humans. Studies on e-waste induced DNA damage in plants have been limited to the use of the Allium cepa assay; while different cell lines such as the human promonocytic leukemia cell line, the fibroblast (NIH 3T3) cell line and human peripheral blood lymphocytes have been utilized to show that e-waste can induce various forms of genetic damages. Genetic studies using fish and mice further showed that e-waste induced somatic and germ cell mutations. In humans, studies have shown that e-waste induced chromosomal aberrations, micronuclei, testicular dysfunction and prostate cancer; altered gene expression and reduced placental telomere length. Since e-waste accumulation is on the increase with possible complex combinatorial effects of its toxicants, this review addresses the need for assessment of the potential DNA damaging effects of such an unprecedented exposure scenario. In this review, we surveyed the literature to provide updated information on e-waste's potential DNA damaging effect in different organisms, both in vitro and in vivo. The review buttressed the fact that e-waste is hazardous; hence, disposal and recycling should be properly monitored. Further studies are necessary to unravel and have a holistic view of the 'potential genetic danger posed by e-waste constituents in living organisms, as well as the possible mechanism of DNA damage.
- Subjects
ELECTRONIC waste; PUBLIC health; GLOBAL environmental change; POISONS; HAZARDOUS substances
- Publication
Environmental Research Journal, 2017, Vol 11, Issue 3, p161
- ISSN
1935-3049
- Publication type
Article