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- Title
Traditional Chinese medicine in the era of immune checkpoint inhibitor: theory, development, and future directions.
- Authors
Yu, Yi-xuan; Wang, Shuo; Liu, Zhe-ning; Zhang, Xu; Hu, Zi-xin; Dong, Hui-jing; Lu, Xing-yu; Zheng, Jia-bin; Cui, Hui-juan
- Abstract
Immune checkpoint inhibitors (ICIs) have revolutionized cancer management and have been widely applied; however, they still have some limitations in terms of efficacy and toxicity. There are multiple treatment regimens in Traditional Chinese Medicine (TCM) that play active roles in combination with Western medicine in the field of oncology treatment. TCM with ICIs works by regulating the tumor microenvironment and modulating gut microbiota. Through multiple targets and multiple means, TCM enhances the efficacy of ICIs, reverses resistance, and effectively prevents and treats ICI-related adverse events based on basic and clinical studies. However, there have been few conclusions on this topic. This review summarizes the development of TCM in cancer treatment, the mechanisms underlying the combination of TCM and ICIs, existing studies, ongoing trials, and prospects for future development.
- Subjects
PREVENTION of drug side effects; DRUG efficacy; IMMUNE checkpoint inhibitors; HERBAL medicine; GUT microbiome; ANTINEOPLASTIC agents; DRUG resistance; CELL physiology; DRUG synergism; TUMORS; DRUG development; CELL lines; CHINESE medicine; DRUG toxicity; IMMUNOTHERAPY
- Publication
Chinese Medicine, 2023, Vol 18, Issue 1, p1
- ISSN
1749-8546
- Publication type
Article
- DOI
10.1186/s13020-023-00751-7