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- Title
Autworks: a cross-disease network biology application for Autism and related disorders.
- Authors
Nelson, Tristan H.; Jae-Yoon Jung; DeLuca, Todd F.; Hinebaugh, Byron K.; Che St. Gabriel, Kristian; Wall, Dennis P.
- Abstract
Background: The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results. Description: We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/ diseases, and upload their own sets for comparative analysis. Conclusions: Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders. Availability: http://autworks.hms.harvard.edu/
- Subjects
AUTISM; DEVELOPMENTAL disabilities; WEB portals; GENES; MOLECULAR biology; VISUAL perception
- Publication
BMC Medical Genomics, 2012, Vol 5, Issue 1, p56
- ISSN
1755-8794
- Publication type
Article
- DOI
10.1186/1755-8794-5-56